Practical and Efficient Synthesis of 4, 4′-Dihydroxy-3, 3′-dinitrodiphenyl Ether and 1, 3-bis (4-Hydroxy-3-nitrophenoxy) benzene in Aqueous Alkaline Medium

…, M Takeda, A Tamaki, H Taniguchi…

Index: Imoto, Mitsutaka; Takeda, Motonori; Tamaki, Akihiro; Taniguchi, Hisaji; Mizuno, Kazuhiko Organic Preparations and Procedures International, 2010 , vol. 42, # 2 p. 161 - 167

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Abstract

4, 4-Dihydroxy-3, 3-dinitrodiphenyl ether (4) and 1, 3-bis (4-hydroxy-3-nitrophenoxy) benzene (9) are valuable precursors of 3, 3-diamino-4, 4-dihydroxydiphenyl ether1 (5) and 1, 3-bis (3-amino-4-hydroxyphenoxy) benzene2 (10) respectively. The latter two compounds are interesting because of their amphoteric properties in acid-base behavior3 and as precursors of symmetrical bisphenolic Mannich derivatives of biological interest. 4 ...