8, 9-methylenedioxybenzo [i] phenanthridines: topoisomerase I-targeting activity and cytotoxicity

D Li, B Zhao, SP Sim, TK Li, A Liu, LF Liu…

Index: Li, Dajie; Zhao, Baoping; Sim, Sai-Peng; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 17 p. 3795 - 3805

Full Text: HTML

Citation Number: 35

Abstract

Substituted benzo [i] phenanthridines that have incorporated within their structure an 8, 9- methylenedioxy group can exhibit topoisomerase I-targeting activity. Structure–activity studies were performed to examine the influence of saturation at the 11, 12-positions of several substituted 8, 9-methylenedioxybenzo [i] phenanthridines. The activities of these dihydro analogues were compared to those of their unsaturated analogues. In addition, ...