Evolution of a series of peptidoleukotriene antagonists: Synthesis and structure-activity relationships of 1, 6-disubstituted indoles and indazoles

FJ Brown, YK Yee, LA Cronk, KC Hebbel…

Index: Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1771 - 1781

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Citation Number: 43

Abstract

... Fisons' proto- typical antagonist FPL 55712 (Chart I), a hydroxyaceto- phenone-chromone, never advanced beyond the stage of a valuable pharmaceutical tool, primarily because of a short biological half-life. ... Page 2. 1772 Journal of Medicinal Chemistry, 1990, Vol. ...