Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity

AT Baviskar, UC Banerjee, M Gupta, R Singh…

Index: Baviskar, Ashish T.; Banerjee, Uttam C.; Gupta, Mukesh; Singh, Rajveer; Kumar, Sunil; Gupta, Manish K.; Kumar, Sanjeev; Raut, Satish K.; Khullar, Madhu; Singh, Sandeep; Kumar, Raj Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5782 - 5793

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Citation Number: 15

Abstract

Abstract Design, synthesis and anticancer activity of a series of imine-pyrazolopyrimidinones is reported for the first time. Compounds 9d, 9n and 9o in the series show encouraging in vitro anticancer activity with low micromolar IC 50 values against prostate (PC3) and breast (MCF7) cancer cell lines. Some notions about structure–activity relationships and plausible mechanism of biological activity are presented.