Hydrolysis of dideoxygenated purine nucleosides: effect of modification of the base moiety

V Nair, GS Buenger

Index: Nair, Vasu; Buenger, Greg S. Journal of Organic Chemistry, 1990 , vol. 55, # 11 p. 3695 - 3697

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Citation Number: 42

Abstract

Studies of the glycosidic bond hydrolysis of the dideoxynucleosides were carried out at pH 3 and 22" C, where easily observable rates could be obtained. The reactions were followed by differential UV spectroscopy (Figure 1). Samples were monitored at appropriate time intervals by adjusting the pH to 13, thus separating the absorption of the unchanged nucleoside from that of the bathochromically shifted hydrolyzed base anion. For example, ...