Mimicking enzymes: cooperation between organic functional groups and metal ions in the cleavage of phosphate diesters

M Livieri, F Mancin, G Saielli, J Chin…

Index: Livieri, Monica; Mancin, Fabrizio; Saielli, Giacomo; Chin, Jik; Tonellato, Umberto Chemistry - A European Journal, 2007 , vol. 13, # 8 p. 2246 - 2256

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Citation Number: 74

Abstract

Abstract A series of ligands derived from the bis-2-pyridinylmethylamine structure, which bear either additional hydroxyl or aromatic amino groups, were prepared and their Zn II complexes were studied as catalysts for the cleavage of bis-p-nitrophenyl phosphate (BNP) and 2-hydroxypropyl-p-nitrophenyl phosphate (HPNP) diesters. A comparative kinetic study indicated that the insertion of organic groups, capable of acting as nucleophiles or as ...