First Regioselective C??2 Lithiation of 3??and 4??Chloropyridines

S Choppin, P Gros, Y Fort

Index: Choppin, Sabine; Gros, Philippe; Fort, Yves European Journal of Organic Chemistry, 2001 , # 3 p. 603 - 606

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Citation Number: 35

Abstract

Abstract We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3-and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lithiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2, 3-and 2, 4- disubstituted pyridines.