Synthesis and Antiprotozoal Activity of N-Alkoxy Analogues of the Trypanocidal Lead Compound 4, 4′-Bis (imidazolinylamino) diphenylamine with Improved Human …
L Nieto, A Mascaraque, F Miller, F Glacial…
Index: Nieto, Lidia; Mascaraque, Ainhoa; Miller, Florence; Glacial, Fabienne; Rios Martinez, Carlos; Kaiser, Marcel; Brun, Reto; Dardonville, Christophe Journal of Medicinal Chemistry, 2011 , vol. 54, # 2 p. 485 - 494
Full Text: HTML
Citation Number: 20
Abstract
To improve the blood− brain barrier permeability of the trypanocidal lead compound 4, 4′- bis (imidazolinylamino) diphenylamine (1), five N-alkoxy analogues were synthesized from bis (4-isothiocyanatophenyl) amine and N-alkoxy-N-(2-aminoethyl)-2- ...
Related Articles:
Synthesis, regioselective deprotonation, and stereoselective alkylation of fluoro ketimines
[Welch, John T.; Seper, Karl W. Journal of Organic Chemistry, 1988 , vol. 53, # 13 p. 2991 - 2999]
Stereoselective cyclization reactions of IBX-generated alkoxyamidyl radicals
[Janza, Birgit; Studer, Armido Journal of Organic Chemistry, 2005 , vol. 70, # 17 p. 6991 - 6994]
Hydroxylamine Chemistry. IV. O-Aralkylhydroxylamines
[Journal of Medicinal Chemistry, , vol. 7, p. 329 - 334]
Synthesis, regioselective deprotonation, and stereoselective alkylation of fluoro ketimines
[Journal of Organic Chemistry, , vol. 53, # 13 p. 2991 - 2999]
[Journal of the American Chemical Society, , vol. 127, # 15 p. 5528 - 5539]