Helical Peptide-Foldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups

…, M Nagano, H Suemune, M Tanaka

Index: Nagano, Masanobu; Tanaka, Masakazu; Doi, Mitsunobu; Demizu, Yosuke; Kurihara, Masaaki; Suemune, Hiroshi Organic Letters, 2009 , vol. 11, # 5 p. 1135 - 1137

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Citation Number: 9

Abstract

A chiral five-membered ring α, α-disubstituted α-amino acid (R, R)-Ac5cdN3 having two azido functional groups has been designed and synthesized. The cyclic amino acid (R, R)- Ac5cdN3 could be efficiently converted into several cyclic amino acids with various two 1, 2, 3-triazole functional groups.(R, R)-Ac5cdN3 homochiral peptides (up to hexapeptide) and (R, R)-Ac5cdN3-containing l-Leu-based peptides were prepared, and their conversion of ...