Synthesis and Evaluation of the Cytotoxicities of Neoflavenes

…, JC Tsai, LY Chen, EC Wang, YT Huang…

Index: Li, Sie-Rong; Chen, Hsing-Ming; Chen, Po-Yuan; Tsai, Jui-Chi; Chen, Liang-Yeu; Wang, Eng-Chi; Huang, Yi-Ting; Wei, Yun-Chen; Lu, Pei-Jung Journal of the Chinese Chemical Society, 2008 , vol. 55, # 4 p. 923 - 932

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Citation Number: 2

Abstract

Abstract The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described. As starting materials, various salicylaldehydes were run through sequential reactions such as O-allylation, Grignard reaction, oxidation, Wittig reaction, and ring-closing metathesis to yield the target neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4′-methoxyneoflavene (6e) and 8-methoxy-4′- ...