Practical enantiospecific synthesis of RPR 111905: A novel non-peptide substance P antagonist
S Mutti, C Daubié, J Malpart, X Radisson
Index: Mutti, Stephane; Daubie, Christophe; Malpart, Joel; Radisson, Xavier Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8743 - 8746
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Citation Number: 9
Abstract
Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The synthesis of enantiomerically pure RPR 111905 was achieved in twelve steps with an overall yield of 6.9%. The synthetic strategy was based on a Diels-Alder reaction to generate the bicyclic framework and the asymmetry was introduced by resolution.
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