Chemoenzymatic dynamic kinetic resolution of primary amines

J Paetzold, JE Bäckvall

Index: Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E. Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825

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Citation Number: 231

Abstract

An efficient process for dynamic kinetic resolution of amines was developed by combining a ruthenium-catalyzed racemization with a lipase-catalyzed resolution. A variety of unfunctionalized primary amines were transformed into one enantiomer of the amide in high yield and high enantioselectivity.

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