Synthesis and preliminary pharmacological evaluation of 4′-arylalkyl analogues of clozapine. IV. The effects of aromaticity and isosteric replacement

B Capuano, IT Crosby, EJ Lloyd, A Podloucka…

Index: Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Podloucka, Anna; Taylor, David A. Australian Journal of Chemistry, 2008 , vol. 61, # 12 p. 930 - 940

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Citation Number: 11

Abstract

Abstract We report the synthesis and preliminary pharmacological activity of a new series of tricyclic analogues of clozapine as potential antipsychotic agents for the treatment of schizophrenia. These compounds were designed based on a revised structural model, and investigate the length and nature of a designated linker (alkyl and alkyloxy) and the nature of the introduced aryl group (aromatic and heteroaromatic). The chemistry and structural ...