Asymmetric biocatalysis of S-3-amino-3-phenylpropionic acid with new isolated Methylobacterium Y1-6
Y Li, W Wang, Y Huang, Q Zou, G Zheng
Index: Li, Yi; Wang, Wenfu; Huang, Yumian; Zou, Qianwen; Zheng, Guojun Process Biochemistry, 2013 , vol. 48, # 11 p. 1674 - 1678
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Abstract
Abstract β-amino acids are widely used in drug research, and S-3-amino-3-phenylpropionic acid (S-APA) is an important pharmaceutical intermediate of S-dapoxetine, which has been approved for the treatment of premature ejaculation. Chiral catalysis is an excellent method for the preparation of enantiopure compounds. In this study, we used (±)-ethyl-3-amino-3- phenylpropanoate (EAP) as the sole carbon source. Three hundred thirty one ...
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