Modular Solid??Phase Synthesis of Teroxazoles as a Class of α??Helix Mimetics

…, A Metz, JW Bats, H Gohlke, MW Göbel

Index: Pinto Gomes, Cristiano; Metz, Alexander; Bats, Jan W.; Gohlke, Holger; Goebel, Michael W. European Journal of Organic Chemistry, 2012 , # 17 p. 3270 - 3277

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Citation Number: 6

Abstract

Abstract α-Helices are ubiquitous structural elements of proteins and are important in molecular recognition. Small molecules mimicking α-helices have proven to be valuable biophysical probes or modulators of protein-protein interactions. Here, we present modeling studies and the modular solid-phase synthesis of teroxazole derivatives as a new class of α- helix mimetics. The synthesis is compatible with a variety of functional groups and should ...