Zinc cyanide mediated direct α-cyanation of isonicotinic acid N-oxide. Application to the synthesis of FYX-051, a xanthine oxidoreductase inhibitor
Z Huo, T Kosugi, Y Yamamoto
Index: Huo, Zhibao; Kosugi, Teruo; Yamamoto, Yoshinori Tetrahedron Letters, 2008 , vol. 49, # 28 p. 4369 - 4371
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Citation Number: 10
Abstract
Reaction of isonicotinic acid N-oxide 1a with dimethylcarbamoyl chloride and zinc cyanide in CH3CN at 120° C gave the corresponding 2-cyanoisonicotinamide 2a in a good yield. This strategy was applied to the synthesis of FYX-051· TsOH 8, a xanthine oxidoreductase inhibitor.
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