Bioorganic & medicinal chemistry letters

Efficient synthesis of antifungal active 9-substituted-3-aryl-5H, 13aH-quinolino [3, 2-f][1, 2, 4] triazolo [4, 3-b][1, 2, 4] triazepines in ionic liquids

M Gupta

Index: Gupta, Monika Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 16 p. 4919 - 4923

Full Text: HTML

Citation Number: 11

Abstract

The title compounds, 9-substituted-3-aryl-5H, 13aH-quinolino [3, 2-f][1, 2, 4] triazolo [4, 3- b][1, 2, 4] triazepines 8, are synthesized from 5-aryl-3, 4-diamino-1, 2, 4-triazoles 5 and 2- chloro-3-formylquinolines 7 in ionic liquid as solvent under microwave heating as well as using oil-bath heating at 80° C. The products are obtained in the good to moderate yields and in high purity. These compounds have been screened for antifungal activity. The ...