Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study

…, L Viornery, C Bayet, G Comte-Sarrazin…

Index: Daskiewicz, Jean-Baptiste; Depeint, Flore; Viornery, Lionel; Bayet, Christine; Comte-Sarrazin, Geraldine; Comte, Gilles; Gee, Jennifer M.; Johnson, Ian T.; Ndjoko, Karine; Hostettmann, Kurt; Barron, Denis Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2790 - 2804

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Citation Number: 114

Abstract

A library of 42 natural and synthetic flavonoids has been screened for their effect on cell proliferation and apoptosis in a human colonic cell line (HT-29). Examples of different classes of flavonoids have been screened, and the effects of hydroxylation, methoxylation and/or C-alkylation at various positions in the A-and B-rings have been assessed. Flavones and flavonols possess greater antiproliferative activity than chalcones and flavanones. ...