Efficient synthesis of the immunosuppressive agent FTY720

S Kim, H Lee, M Lee, T Lee

Index: Kim, Sanghee; Lee, Hyeseung; Lee, Minhee; Lee, Taeho Synthesis, 2006 , # 5 p. 753 - 755

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Citation Number: 18

Abstract

Abstract The concise and practical synthesis of the biologically important FTY720 was achieved employing the palladium-catalyzed Sonogashira coupling reaction as a key step. The commercial tris (hydroxymethyl) aminomethane was converted to alkyne 2 via a three- step synthesis. The coupling reactions of alkyne 2 with aryl iodide 3, followed by subsequent hydrogenation of the internal alkyne and removal of the protecting groups provided ...