On the preparation of some phospholipid analogues

…, RT Freeman, J Russell, PG Sammes

Index: Browne, Judith E.; Freeman, Richard T.; Russell, Jeremy C.; Sammes, Peter G. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 5 p. 645 - 652

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Abstract

Several structural analogues of the biocompatible diacyl glycerol phosphatidylcholine family have been prepared. Considerable variation in structure is allowed without impairing the desirable biocompatible properties. In particular, derivatives in which the fatty ester link is replaced by ether links and in which the central glycerol group is replaced by simple variants such as the symmetrical tris (hydroxymethyl) ethane group retain biocompatible properties.