3-Benzamido, ureido and thioureidoimidazo [1, 2-a] pyridine derivatives as potential antiviral agents.

A Chaouni-Benabdallah, C Galtier…

Index: Chaouni-Benabdallah, Aziz; Galtier, Christophe; Allouchi, Hassan; Kherbeche, Abdelak; Chavignon, Olivier; Teulade, Jean-Claude; Witvrouw, Myriam; Pannecouque, Christophe; Snoeck, Robert; Andrei, Graciela; Balzarini, Jan; De Clercq, Erik; Fauvelle, Florence; Enguehard, Cecile; Gueiffier, Alain Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1631 - 1635

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Citation Number: 18

Abstract

This work reports the synthesis and the antiviral activities of 3-benzamido, 3-phenylureido and 3-phenyl-thioureido derivatives in the imidazo [1, 2-a] pyridine series. The structure was proven by NMR spectroscopy. The synthesized compounds were evaluated against a large number of viruses. The 3-phenylthioureido derivative 7 showed moderate activity against human cytomegalovirus (HCMV) in vitro. The crystallographic data for 8 are also reported ...