Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone

…, JK Swartzendruber, ND Jones, TK Elzey…

Index: Robertson, David W.; Beedle, E. E.; Swartzendruber, John K.; Jones, Noel D.; Elzey, T. K.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 635 - 640

Full Text: HTML

Citation Number: 62

Abstract

The cardiotonic drug milrinone (1, 6-dihydro-2-methyl-6-0~ 0-[3, 4'-bipyridine]-5-~ arbonitrile) is superior to its analogue amrinone (5-amino-[3, 4'-bipyridin]-6 (lZf)-one) by virtue of its greater potency and reduced side effect profile. We confirmed initial reports on the potencies of milrinone and amrinone and found that after intravenous administration to phenobarbital anesthetized dogs, the drugs had cumulative inotropic ED,,'s of 37 and ...