Chinese Chemical Letters

A copper-and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand

WP Mai, JW Yuan, ZC Li, GC Sun

Index: Mai, Wen Peng; Yuan, Jin Wei; Li, Zhi Cheng; Sun, Gang Chun Chinese Chemical Letters, 2012 , vol. 23, # 2 p. 185 - 188

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Citation Number: 2

Abstract

An efficient palladium-catalyzed copper-and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand. The use of 2mol% Pd (OAc) 2 in the presence of K2CO3 allows the coupling reaction to proceed at mild condition with good to excellent yields.

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