A practical synthesis of multitargeted antifolate LY231514

CJ Barnett, TM Wilson…

Index: Organic Process Research and Development, , vol. 3, # 3 p. 184 - 188

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Citation Number: 45

Abstract

... Our synthetic scheme for utilization of the haloaldehyde cyclocondensation process in the synthesis of ... directly in a TEMPO 10 -catalyzed sodium hypochlorite oxidation 11 procedure, providing the ... The organic layer was washed with 260 L of 5% sodium bicarbonate solution ...

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