Alternative Synthesis of the Cycloisodityrosine Subunit of Deoxybouvardin, RA-VII, and Related Agents: Reassignment of the Stereochemistry of Prior Intermediates

DL Boger, J Zhou

Index: Journal of Organic Chemistry, , vol. 61, # 12 p. 3938 - 3939

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Citation Number: 39

Abstract

... 45-50 °C, 2-4 h) or NaH (2.2 equiv, 0.004 M THF, 2-6 h) led to smooth 14-membered ring closure (Scheme 1). In the case of 2, both conditions provided a single product 3 in superb conversions (76-78%), and the relative stereo- chemistry was unambiguously ... J. Org. Chem., Vol. ...