Tetrahedron letters

Open vessel mode microwave-assisted synthesis of 2-oxazolines from carboxylic acids

R Sharma, SK Vadivel, RI Duclos, A Makriyannis

Index: Sharma, Rishi; Vadivel, Subramanian K.; Duclos Jr., Richard I.; Makriyannis, Alexandros Tetrahedron Letters, 2009 , vol. 50, # 42 p. 5780 - 5782

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Citation Number: 15

Abstract

Microwave-assisted synthesis of 2-oxazolines from carboxylic acids using the open vessel technique is described. This efficient method involves direct condensation of carboxylic acids with excess 2-amino-2-methyl-1-propanol at 170° C to give the corresponding 2- oxazolines in moderate to excellent yields.