Topical carbonic anhydrase inhibitors
RD Schoenwald, MG Eller, JA Dixson…
Index: Schoenwald; Eller; Dixson; Barfknecht Journal of Medicinal Chemistry, 1984 , vol. 27, # 6 p. 810 - 812
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Citation Number: 36
Abstract
Discussion Our approach to the development of a topically effective carbonic anhydrase inhibitor involves selecting a suitable prototype molecule, making single molecular modifications of that structure, determining various physical and biological properties of each analogue, and finally utilizing the data to design a molecule with the best combination of properties. When 1 is applied topically to the eye it is inactive. In ow initial studies, we ...
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