Bioorganic & medicinal chemistry letters

A short synthesis of argatroban: a potent selective thrombin inhibitor

J Cossy, D Belotti

Index: Cossy, Janine; Belotti, Damien Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 15 p. 1989 - 1992

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Citation Number: 14

Abstract

Argatroban was synthesized in seven steps from 4-methylpiperidine. The condensation of (±)-trans-benzyl 4-methylpipecolic acid ester with N α -Boc-N ω -nitro-l-arginine led to two diastereomers that were separated. One of them is the precursor of argatroban. ... 4-Methylpipecolic acid ester with N α -Boc-N ω -l-nitro arginine led to two diastereomers that were separated. One of them is the precursor of argatroban. ... Thrombotic vascular disease is a major cause of ...