Synthesis and cytotoxic activity of 7-oxo-7 H-dibenz [f, ij] isoquinoline and 7-oxo-7 H-benzo [e] perimidine derivatives

X Bu, LW Deady, GJ Finlay, BC Baguley…

Index: Bu; Deady; Finlay; Baguley; Denny Journal of Medicinal Chemistry, 2001 , vol. 44, # 12 p. 2004 - 2014

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Citation Number: 77

Abstract

A series of 7-oxo-7 H-dibenz [f, ij] isoquinoline and 7-oxo-7 H-benzo [e] perimidines bearing cationic side chains were prepared from aminoanthraquinones. The perimidines were prepared from 1-aminoanthraquinone by initial condensation with urea or dimethylacetamide. A series of 2-, 4-, 8-, and 11-carboxy derivatives of the dibenzisoquinolines were prepared from aminoanthraquinonecarboxylic acids. The ...

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