Synthesis and Cytotoxicity Evaluation of Some Novel 3, 5-disubstituted-1, 2, 4-Oxadiazoles

M Siva Nagi Reddy, B Sailaja Kumari…

Index: Reddy, M. Siva Nagi; Kumari, B. Sailaja; Babu, B. Hari Letters in Drug Design and Discovery, 2012 , vol. 9, # 10 p. 942 - 946

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Citation Number: 3

Abstract

Novel 3, 5-disubstituted 1, 2, 4-oxadiazoles 4a-4j were prepared from commercially available chlorosalicylaldehyde and screened for their cytotoxicity properties using brine shrimp (Artemia salina) bioassay and compared with the standard podophyllotoxin. The oxadiazoles 4a, 4c, 4e and 4h exhibited cytotoxicity activity in the series.