Discovery of potent, soluble and orally active TRPV1 antagonists. Structure–activity relationships of a series of isoxazoles

P Ratcliffe, L Abernethy, N Ansari, K Cameron…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 15 p. 4652 - 4657

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Citation Number: 10

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... 6 Consequently, TRPV1 is believed to act as an integrator of nociceptive responses to both chemical and thermal noxious stimuli. 7. ...