Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives

…, WJ Zembrowski, TA Beyer, CE Aldinger…

Index: Mylari, Banavara L.; Zembrowski, William J.; Beyer, Thomas A.; Aldinger, Charles E.; Siegel, Todd W. Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2155 - 2162

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Citation Number: 40

Abstract

Benzothiazole side chains featured in zopolrestat (la) and ita congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety. Potent aldose reductase inhibition activity among resulting compounds is as widespread as it is in the earlier mpolrestat series, thus lending further support to our hypothesis that there is a binding site on the aldose ...