Tetrahedron Letters

Facile three-component domino reactions for the synthesis of 2-arylimidazo [1, 2-a] pyridines and 2-arylimidazo [2, 1-a] isoquinolines

P Prasanna, SV Kumar, P Gunasekaran, S Perumal

Index: Prasanna, Pitchaimani; Kumar, Sundaravel Vivek; Gunasekaran, Pethaiah; Perumal, Subbu Tetrahedron Letters, 2013 , vol. 54, # 29 p. 3740 - 3743

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Citation Number: 10

Abstract

The three-component domino reactions of pyridine/isoquinoline, phenacyl bromide, and substituted (E)-N-hydroxyarylimidoyl chloride in the presence of triethylamine afforded a series of 2-arylimidazo [1, 2-a] pyridines and 2-arylimidazo [2, 1-a] isoquinolines. This one pot three-component transformation presumably proceeds via ylide generation/annulation/ fragmentation/dehydration domino sequence of reactions.

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