Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication

…, M Prhavc, J Brooks, B Bhat, TP Prakash…

Index: Eldrup, Anne B.; Prhavc, Marija; Brooks, Jennifer; Bhat, Balkrishen; Prakash, Thazha P.; Song, Quanlai; Bera, Sanjib; Bhat, Neelima; Dande, Prasad; Cook, P. Dan; Bennett, C. Frank; Carroll, Steven S.; Ball, Richard G.; Bosserman, Michele; Burlein, Christine; Colwell, Lawrence F.; Fay, John F.; Flores, Osvaldo A.; Getty, Krista; LaFemina, Robert L.; Leone, Joseph; MacCoss, Malcolm; McMasters, Daniel R.; Tomassini, Joanne E.; Von Langen, Derek; Wolanski, Bohdan; Olsen, David B. Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5284 - 5297

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Citation Number: 174

Abstract

Hepatitis C virus infection constitutes a significant health problem in need of more effective therapies. We have recently identified 2'-C-methyladenosine and 2'-C-methylguanosine as potent nucleoside inhibitors of HCV RNA replication in vitro. However, both of these compounds suffered from significant limitations. 2'-C-Methyladenosine was found to be susceptible to enzymatic conversions by adenosine deaminase and purine nucleoside ...