Tetrahedron Letters

K 2 PdCl 4 catalyzed efficient multicomponent synthesis of α-aminonitriles in aqueous media

B Karmakar, J Banerji

Index: Karmakar, Bikash; Banerji, Julie Tetrahedron Letters, 2010 , vol. 51, # 20 p. 2748 - 2750

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Citation Number: 32

Abstract

An efficient, mild and environmentally friendly method has been developed for the Strecker reaction to synthesize α-aminonitriles in the presence of K2PdCl4 as a catalyst. The three- component one-pot condensation of an aldehyde, amine and trimethylsilyl cyanide proceeded smoothly in water to afford the corresponding product in high yield with short reaction times.