Synthesis of fluorescent c 24-ceramide: evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin

J Novotný, K Pospěchová, A Hrabálek, R Čáp…

Index: Novotny, Jakub; Pospechova, Katerina; Hrabalek, Alexandr; Cap, Robert; Vavrova, Katerina Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6975 - 6977

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Citation Number: 26

Abstract

Topical skin lipid supplementation may provide opportunities for controlling ceramide (Cer) deficiency in skin diseases such as atopic dermatitis or psoriasis. Here we describe the synthesis of a long-chain 7-nitrobenzo [c][1, 2, 5] oxadiazol-4-yl (NBD)-labeled Cer and its different penetration through human skin compared to widely used short-chain fluorescent Cer tools.