Molecular recognition in the P2Y 14 receptor: probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose

…, J Hajduch, KL Kirk, TK Harden, KA Jacobson

Index: Ko, Hyojin; Das, Arijit; Carter, Rhonda L.; Fricks, Ingrid P.; Zhou, Yixing; Ivanov, Andrei A.; Melman, Artem; Joshi, Bhalchandra V.; Kovac, Pavol; Hajduch, Jan; Kirk, Kenneth L.; Harden, T. Kendall; Jacobson, Kenneth A. Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 5298 - 5311

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Citation Number: 22

Abstract

The P2Y14 receptor, a nucleotide signaling protein, is activated by uridine-5′- diphosphoglucose 1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the most structurally permissive region for designing analogues of this P2Y14 agonist. For example, the carboxylate group of uridine-5′-diphosphoglucuronic acid proved to be suitable for flexible substitution by chain extension through an amide linkage. ...