Tetrahedron

Synthesis and biological evaluation of glycosylated psoralen derivatives

CY Chen, JG Sun, FY Liu, KP Fung, P Wu, ZZ Huang

Index: Chen, Chao-Yue; Sun, Jian-Guo; Liu, Fei-Yan; Fung, Kwok-Pui; Wu, Ping; Huang, Zhi-Zhen Tetrahedron, 2012 , vol. 68, # 12 p. 2598 - 2606

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Citation Number: 7

Abstract

A novel route for the efficient synthesis of a target psoralen moiety, 4, 4′- dimethylxanthotoxol, has been developed, which need only four steps using cheap pyrogallol as a starting material. Subsequently, a range of new glycosylated psoralen derivatives were synthesized in good yields with simple procedures and mild reaction conditions. The experiment of biological activity shows that some of the glycosylated ...