Electrogenerated Chiral 4??Methoxy??2??oxazolidinones as Diastereoselective Amidoalkylation Reagents for the Synthesis of β??Amino Alcohol Precursors
K Schierle??Arndt, D Kolter…
Index: Schierle-Arndt, Kerstin; Kolter, Doris; Danielmeier, Karsten; Steckhan, Eberhard European Journal of Organic Chemistry, 2001 , # 13 p. 2425 - 2433
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Citation Number: 8
Abstract
Abstract A flexible and efficient synthesis of enantiomerically pure 4, 5-substituted 2- oxazolidinones− important target molecules as precursors of pharmacologically active 2- oxazolidinones, β-amino alcohols, β-blockers and azasugar derivatives− is described. As starting materials, the enantiopure storage forms of chiral N-acyliminium ions (4RS, 5S)-5- chloromethyl-4-methoxy-1, 3-oxazolidin-2-one (2) and (4RS, 5R)-4-methoxy-5-methyl-1, 3 ...
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