Tetrahedron letters

A novel approach to the synthesis of optically pure non protein α-amino acids in both L and D configurations from L-serine

NA Sasaki, C Hashimoto, P Potier

Index: Sasaki, N.Andre; Hashimoto, Chiyomi; Potier, Pierre Tetrahedron Letters, 1987 , vol. 28, # 48 p. 6069 - 6072

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Citation Number: 82

Abstract

Abstract Efficient syntheses of (2R)-2-Boc-amino-3-phenylsulfonyl-l-propanol 3 and its enantiomer 9 from L-serine are described. The potential of these compounds in a novel general method for the synthesis of optically pure non protein α-amino acids in both the L and D configurations is exemplified by the preparation of N-Boc-L-and D- homophenylalanine,-norvaline and-norleucine.