Enantioselective synthesis of brinzolamide (AL-4862), a new topical carbonic anhydrase inhibitor. The “DCAT Route” to thiophenesulfonamides

RE Conrow, WD Dean, PW Zinke…

Index: Organic Process Research and Development, , vol. 3, # 2 p. 114 - 120

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Citation Number: 20

Abstract

... THF at −10 °C, followed by stirring at this temperature for 4 h, simulating a process delay ... 18 (Scheme 3), which by virtue of the ionizable NH was isolable from neutral organic materials by ... and amination steps also proceeded well in ethyl acetate, so a one-flask procedure for the ...