Synthesis of high-specific-radioactivity 4-and 6-[18 F] fluorometaraminol-PET tracers for the adrenergic nervous system of the heart

…, F Vaufrey, C Fuseau, C Coulon, M Ottaviani…

Index: Langer, Oliver; Dolle, Frederic; Valette, Heric; Halldin, Christer; Vaufrey, Francoise; Fuseau, Chantal; Coulon, Christine; Ottaviani, Michele; Nagren, Kjell; Bottlaender, Michel; Maziere, Bernard; Crouzel, Christian Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 677 - 694

Full Text: HTML

Citation Number: 43

Abstract

Fluorine-18-(t1/2 109.8 min) and carbon-11 (t1/2 20.4 min)-labeled norepinephrine analogues have been found previously to be useful positron-emission-tomography (PET) radioligands to map adrenergic nerve terminals of the heart. Metaraminol ((1R, 2S)-2-amino- 1-(3-hydroxyphenyl)-1-propanol) is a metabolically stable structural analogue of norepinephrine and possesses high affinity towards the norepinephrine transporter and ...