Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

H Peng, D Carrico, V Thai, M Blaskovich…

Index: Organic and Biomolecular Chemistry, , vol. 4, # 9 p. 1768 - 1784

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Citation Number: 42

Abstract

... 1 Chemical structures of PGGTase-I inhibitors. ... Chemistry. ... Compounds 13b–13d were synthesized from scaffolds 12b–12d, respectively, under similar conditions using 4-chloromethyl-5-methyl- 1-tritylimidazole 9. Hydrogenation at atmospheric pressure using 10% Pd/C removed ...