Preparation and structure-activity relationships of simplified analogs of the antifungal agent cilofungin: a total synthesis approach

RA Zambias, ML Hammond, JV Heck…

Index: Zambias, Robert A.; Hammond, Milton L.; Heck, James V.; Bartizal, Ken; Trainor, Charlotte; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2843 - 2855

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Citation Number: 61

Abstract

The echinocandins are a well-known class of lipopeptides characterized by their potent antifungal activity against Candida species. The mechanism of action of the echinocandina is generally thought to be the inhibition of &1, 3-glucan synthesis, an important structural component in the cell wall of Candida species. Extensive structureactivity studies on the fatty acid side chain of echinocandin B (1) led to the preparation of the clinical candidate ...