CuCl-catalyzed one-pot synthesis of 5, 6-dihydropyrazolo [1, 5-c] quinazolines
S Guo, J Wang, Y Li, X Fan
Index: Guo, Shenghai; Wang, Jiliang; Li, Yan; Fan, Xuesen Tetrahedron, 2014 , vol. 70, # 14 p. 2383 - 2388
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Citation Number: 5
Abstract
Abstract A simple and efficient procedure for the preparation of 5, 6-dihydropyrazolo [1, 5-c] quinazolines via CuCl-catalyzed tandem reaction of 5-(2-bromoaryl)-1H-pyrazoles with aldehydes and aqueous ammonia under nitrogen atmosphere has been developed. The usefulness of this novel methodology was showcased by its successful application in the preparation of a potential Eg5 inhibitor.
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