Modification of the 5'position of purine nucleosides. 2. Synthesis and some cardiovascular properties of adenosine-5'-(N-substituted) carboxamides
RN Prasad, DS Bariana, A Fung, M Savic…
Index: Prasad, Raj Nandan; Bariana, Dilbagh S.; Fung, Anthony; Savic, Milica; Tietje, Karin; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 313 - 319
Full Text: HTML
Citation Number: 61
Abstract
We have shown previously that the esters of adenosine-5'-carboxylic acid (10) represent a new class of potent nontoxic coronary vasodilators. For example, the ethyl ester (12), which is active by an intraduodenal or intravenous route in dogs, causes a large increase in coronary sinus POz and coronary blood flow. Because of the pronounced vasoactive properties of the esters of adenosine-5'-carboxylic acid, a systematic study of the ...
Related Articles:
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors
[De Zwart, Maarten; Kourounakis, Angeliki; Kooijman, Huub; Spek, Anthony L.; Link, Regina; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman, Ad P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 8 p. 1384 - 1392]
An efficient convergent synthesis of adenosine-5′-N-alkyluronamides
[Devine, Shane M.; Scammells, Peter J. Tetrahedron, 2008 , vol. 64, # 8 p. 1772 - 1777]
5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors
[De Zwart, Maarten; Kourounakis, Angeliki; Kooijman, Huub; Spek, Anthony L.; Link, Regina; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman, Ad P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 8 p. 1384 - 1392]