Chemoenzymatic Syntheses of Homo??and Heterodimers of AZT and d4T, and Evaluation of Their Anti??HIV Activity
…, JJ Vasseur, S Fernández, M Ferrero…
Index: Taourirte; Lazrek; Vasseur; Ferrero; Fernandez; Gotor Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 959 - 962
Full Text: HTML
Citation Number: 10
Abstract
Homo??and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo??and heterodimer carbamates showed weak anti??HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
Related Articles:
[Mag, Matthias; Engels, Joachim W. Tetrahedron, 1994 , vol. 50, # 34 p. 10225 - 10234]
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines
[Wigerinck, Piet; Aerschot, Arthur Van; Janssen, Gerard; Claes, Paul; Balzarini, Jan; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 868 - 873]
A new synthesis of the anti-AIDS drug AZT from 5-methyluridine
[Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7961 - 7964]
A new synthesis of the anti-AIDS drug AZT from 5-methyluridine
[Chen, Bang-Chi; Quinlan, Sandra L.; Reid, J. Gregory Tetrahedron Letters, 1995 , vol. 36, # 44 p. 7961 - 7964]