Journal of the American Chemical Society

Some 5-Substituted Derivatives of Ethyl 2-Methylnicotinate1

PE Fanta

Index: Fanta Journal of the American Chemical Society, 1953 , vol. 75, p. 737

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Citation Number: 9

Abstract

The reaction of sodium nitromalonaldehyde (I) with ethyl p-aminocrotonate (11) was studied as part of a program of synthesis of new heterocyclic compounds of possible pharmacological interest. The only product isolated from the reaction mixture was ethyl 2- methyl-5-nitronicotinate (111). This is the lirst reported use of sodium nitromalonaldedehvde for the synthesis of a nitropyridine. 2 The