Synthesis and stability of 2-oxoisothiocyanates

V Bobošík, A Piklerová, A Martvoň

Index: Bobosik, Vladimir; Piklerova, Anna; Martvon, Augustin Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 12 p. 3421 - 3425

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Citation Number: 6

Abstract

Abstract Enolizable 2-oxoisothiocyanates Ia-If were prepared from hydrochlorides of amino ketones, containing a hydrogen atom in the α-position, by reaction with thiophosgene in the presence of CaCO 3. At room temperature the enol form of these compounds undergoes slow cyclization to give the isomeric 4-oxazoline-2-thiones IIb-IIf. In the presence of bases this isomerization proceeds rapidly even at room temperature. 2- ...