Tetrahedron

Iridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C–H functionalization

GA Chotana, VA Kallepalli, RE Maleczka, MR Smith

Index: Chotana, Ghayoor A.; Kallepalli, Venkata A.; Maleczka Jr., Robert E.; Smith III, Milton R. Tetrahedron, 2008 , vol. 64, # 26 p. 6103 - 6114

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Citation Number: 45

Abstract

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, additional functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed. High regioselectivities were observed in borylation of 3-and 2, 5-di-substituted thiophenes. ...